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・ Serukalathur Sama
・ Serukeirewa
・ Serule
・ Serum
・ Serum (blood)
・ Serum albumin
・ Serum amyloid A
・ Serum amyloid A1
・ Serum amyloid P component
・ Serum chloride
・ Serum free light-chain measurement
・ Serum Institute of India
・ Serum iron
・ Serum Metabolome Database
・ Serum protein electrophoresis
Serum response factor
・ Serum sickness
・ Serum sickness-like reaction
・ Serum total protein
・ Serum-ascites albumin gradient
・ Serum-derived bovine immunoglobulin/protein isolate
・ Serum-separating tube
・ Serumakkanallur
・ Serumavilangai
・ Serundeng
・ Serupane
・ Serupepeli Naqase
・ Serutan
・ Seruthunai Nayanar
・ Seruvakula


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Serum response factor : ウィキペディア英語版
Serum response factor

Serum response factor, also known as SRF, is a transcription factor.
== Function ==

Serum response factor is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).
SRF is important during the development of the embryo, as it has been linked to the formation of mesoderm. In the fully developed mammal, SRF is crucial for the growth of skeletal muscle. Interaction of SRF with other proteins, such as steroid hormone receptors, may contribute to regulation of muscle growth by steroids. Interaction of SRF with other proteins such as myocardin or Elk-1 may enhance or suppress expression of genes important for growth of vascular smooth muscle.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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